BRLTTY supports the following speech synthesizers:
| Name | Models |
| Alva | Delphi (4nn) |
| Android | text to speech engine |
| BrailleLite | |
| CombiBraille | |
| eSpeak | text to speech engine |
| eSpeak-NG | text to speech engine |
| ExternalSpeech | runs /usr/local/bin/externalspeech |
| Festival | text to speech engine |
| FestivalLite | text to speech engine |
| GenericSay | pipes to /usr/local/bin/say |
| Mikropuhe | text to speech engine |
| Swift | text to speech engine |
| Theta | text to speech engine |
| ViaVoice | text to speech engine |